Top Boards
Account Information
Research Peptides
|
Melanotan II Tan Research Melanotan Headquarters Forum
Melanotan Headquarters studies Melanocortin Peptides. In the body, Alpha-Melanocyte Stimulating Hormone (α-MSH) plays an important role regulating pigment (melanin). Synthetic potent polypeptides (Melanotan II) offer protective response to damage caused by ultraviolet radiation (UVR).
Cosmetic Peptide development strives to reduce cancer rates and aging effect. Photo-protection benefits are extremely significant for sensitive skin types (Fitzpatrick Skin types 1 & 2). Quality of life improvements for select niche has captured attention of the media and general population alike.
Trusted Supplier of Melanotan, Melanotan II and Bremelanotide PT-141 Research Peptides. Review United States Melanocortins for Sale online. Melanotan HQ highlights best-selling peptide molecules targeted for Tanning, Libido and Appetite suppression.
Step by step Melanotan Instruction Guide advocates Melanotan II as a poor sunless tanner. Leading Peptide hormones for tanning skin function alongside diligent photo-therapy. Sunless tanning products are expensive and limit one’s lifestyle. Long-lasting freedom from inflammation is now possible with improved understanding of bio-available research peptides.
Amazing results from systemic peptides Melanotan 2 and PT-141 offer therapeutic avenues for both sexes. Sexual dysfunction disorders are enhanced by neuropeptides targeted for receptors associated with desire. Melanocortin agonists combined with PDE5 supplements prove efficacious with carefully measured therapy. Aligned expectation and cascading signals make for the world’s first synthetic aphrodisiac experience shared by MT-II and PT141 users.
Side effects from Melanotan over-dosage are most commonly nausea, vomiting, lethargy, congestion, upset stomach. Melanotan peptides initiate change at the cellular level, potentially lowering pheomelanin density and altering pigment long term. Join the discussion at Melanotan Headquarters to help advance Peptide Science. Research and share passion for innovative peptides that enhance life, enabling patients to do things they never could before.
Today at 10:38:55 AM by Melanotan | Views: 4 | Comments: 0
Defining MC1R Regulation in Human Melanocytes by Its Agonist α-Melanocortin and Antagonists Agouti Signaling Protein and β-Defensin 3
May 2012
Abstract
The melanocortin 1 receptor (MC1R), a G(s) protein-coupled receptor, has an important role in human pigmentation. We investigated the regulation of expression and activity of the MC1R in primary human melanocyte cultures. Human β-defensin 3 (HBD3) acted as an antagonist for MC1R, inhibiting the α-melanocortin (α-melanocyte-stimulating hormone (α-MSH or Melanotan 2))-induced increase in the activities of adenylate cyclase and tyrosinase, the rate-limiting enzyme for melanogenesis. α-Melanocortin and forskolin, which activate adenylate cyclase, and 12-O-tetradecanoylphorbol-13-acetate, which activates protein kinase C, increased, whereas exposure to UV radiation reduced, MC1R gene and membrane protein expression. Brief treatment with α-MSH resulted in MC1R desensitization, whereas continuous treatment up to 3 hours caused a steady rise in cAMP, suggesting receptor recycling. Pretreatment with agouti signaling protein or HBD3 prohibited responsiveness to α-MSH, but not forskolin, suggesting receptor desensitization by these antagonists. Melanocytes from different donors expressed different levels of the G protein-coupled receptor kinases (GRKs) 2, 3, 5, and 6, as well as β-arrestin 1. Therefore, in addition to the MC1R genotype, regulation of MC1R expression and activity is expected to affect human pigmentation and the responses to UV.
May 16, 2012, 07:11:14 AM by gman22 | Views: 46 | Comments: 1
hi all, i have my mt2, on the info sheet it says to mix 10mg mt2 vile mixed with 1ml of bac water. It then says that 0.1ml is at 10 units on the 1ml needle, on the web page it says 0.1ml is .5mg so this means 500mcg right? yet on the peptide calculator 500mcg is at the 3 tick mark. so as you can tell im very confused and am wondering if i am dosing right as there seems to be conflicting information as far as i can see. any help would be great thanks
May 13, 2012, 01:07:32 PM by megageo | Views: 99 | Comments: 1
Hi all,
The last 4 years i have been using melanotan II with great success. In general i am very pale so you understand melanotan II has completely changed my life as i am finally able to tan without burning. I am male , 32 and from Europe, so i am using Melanotan Magic and Europatan. Last year i used Melanotan Magic and had a great tan lasting a lot of months. This year i started about 3 weeks ago with Melanotan Magic again. For the first time i am having an awful side effect that is bringing me down and do not know what to do really.
My tactic is stable every year, i load around 20mg and then i start the sunbeds. That way i never burn and get a great tan after 4-5 sessions in the sunbeds. Then i maintain for 3-4 months.
This year i started doing the same, going from 0.25mg->0.5mg->0.75mg->1mg per day for loading phase. During the loading phase i don't have sun exposure. So after having around 10mg in me i started having uneven skin tone in my face. Really at this point i cannot understand if there is hyperpigmenation of some areas , leaving the rest seem white, or these are white spots. This is the first time i am having this and of course i am devastated. The skin color differentation is noticeable, if it was in the body, i wouldn't care that much, but on the face... Also these are not rounded or have a specific size.
I have read about Idiopathic Guttate Hypomelanosis, do you think this is my case? At this point i have no idea what to do, my options:
1. Continue loading on melanotan II , start sunbeds ,use accelerators to problematic spots and take it from there
2. Change supplier and try another melanotan II run
3. Drop all melanotan II, get some therapy with cremes for uneven skin tone and forget about tanning this year.
I would appreciate any opinion. Thank you
May 11, 2012, 11:34:54 AM by gman22 | Views: 87 | Comments: 1
hi guys. i got my MT2 today and am planning on injecting tonight. as i have a few freckes im starting off at only doing 100mcg daily. My question is im adding 1mL of bacteria water to the 10mg powder. I have a 0.3mL syringe so do i pull it only to the first line? in other words does tick number mean each line? also should i put the needle directly in perpendicular to the sking because its not as long as the 1mL syringe? Help would be great. thanks all
May 10, 2012, 04:15:48 PM by reallypale | Views: 92 | Comments: 1
Great site! Read all the dosing protocols and everything seems spot on. I mixed 10mg with 2 ml of bac water. starting 100mcg daily. My question is of amount of liquid. I have a 1cc 100u syringe. 100mcg would be 1 tick mark correct? I could barely see any liquid in the syringe. basically felt like injecting nothing! Should I add more bac water to increase the volume of injection. If so, how much more? or is that little tiny amount at the 1 tick mark enough? Thanks
Pages: [1]
|
